Scientist, Mass Spectrometry & Analytical Chemistry

Scientist, Mass Spectrometry & Analytical Chemistry

POSITION SUMMARY

Greenlight Biosciences is developing cutting edge RNA technologies that address global challenges in food security, pollinator safety, and human health. GreenLight is seeking a highly motivated, collaborative, and experienced Scientist – Mass Spectrometry & Analytical Chemistry to join our Analytical Sciences team supporting RNAi product research and development. In this role you will lead a small team focused on the development and execution of LCMS and HPLC methods for the quantification of metabolites (e.g. mycotoxins, phytohormones, etc.), proteins, and formulation components. The successful candidate will have in-depth experience operating, troubleshooting, and developing methods on QQQ and HRMS instruments and have worked with biological molecules in previous roles. Strong interpersonal skills and the ability to thrive in a cross-functional team working to deliver against aggressive deadlines is essential. Experience with various techniques to characterize and quantify proteins is strongly preferred. Strong technical, organizational, and communication skills, and the ability and drive to maintain commitment to scientific excellence and high-quality work in a fast-paced, milestone-driven company are must-haves.

MAJOR RESPONSIBILITIES

• Establish, maintain, and troubleshoot Agilent HPLCs / UHPLCs, Thermo Q Exactive HRMS, and Sciex API5000 QQQ LC-MS/MS instruments, or equivalent systems
• Develop and oversee execution of high-throughput, targeted metabolite assays to support in vitro and in vivo experiments (e.g. analytes such as mycotoxins, plant metabolites, and central carbon intermediates)
• Develop and execute targeted protein quantification assays to confirm mode-of-action of RNAi products and characterize response in target organisms
• Provide expertise in Analytical Chemistry and support the development of assays to quantify various formulation components and support the Formulations R&D team
• Advance the analytical technology and tools within the company to stay at leading edge; focusing on methods for RNA characterization, RNAi mode of action, and global proteomics
• Provide technical guidance and mentorship to one or more Scientists / Research Associates on the team
• Analyze, summarize, and present technical data to manager and other team members
• Stay up to date with scientific and technical development within the field of analytical chemistry

PROFESSIONAL EXPERIENCE / QUALIFICATIONS

• PhD (+2 yrs industry experience) or MSc (+5 yrs industry experience) required
• Extensive hands-on experience with (U)HPLC, HRMS, and LC-MS/MS required, including troubleshooting, operating, and development of analytical methods for biomolecules
• Proficiency with high-throughput LCMS assays for the quantification of metabolites and small molecules

• Proven track record of successful method development, including development of sample extraction methods with acceptable performance criteria is required

• Proficiency with contemporary proteomics software (e.g. MaxQuant, Proteome Discoverer, Skyline, Spectronaut etc.) and proteomics workflows (sample prep, HRMS acquisition, and both labelled and label-free quantification methods) preferred
• Broad protein experience including techniques such as CE, SDS-PAGE, etc. is a plus
• Familiarity with data handling languages (e.g. R, Python) is a plus.

• Strong technical background in biochemistry, with knowledge of nucleic acid chemistry and microbial metabolism strongly preferred

• Must be highly motivated with high quality standards for one’s own work, strong communication skills, and an absolute commitment to team success

Greenlight Biosciences Inc. provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.

GreenLight requires proof of COVID-19 vaccination for its employees consistent with OSHA guidelines.