Senior Research Associate, LNP

POSITION SUMMARY

GreenLight Biosciences is seeking an exceptional, highly motivated candidate to support formulation and process development of delivery of nucleic acid drugs and nanoparticle formulations. The successful candidate will support activities associated with formulation, process development and scaleup of delivery matrices for nucleic acids. The position will support projects with different therapeutic goals that will require tailored delivery solutions. Strong technical, organizational, and communication skills, as well as the ability to develop creative solutions to challenging problems, are essential. Applicant must be a team player able to function in a highly collaborative and fast-paced environment. 

MAJOR RESPONSIBILITIES

• Under direction of scientist, prepare novel delivery formulations loaded with complex nucleic acid cargos.
• Conduct experiments to evaluate those delivery technologies and build a structure-activity know-how around efficacy including in vitro transfection, in vivo administration, and physiochemical properties.
• Explore the impact of the composition and process parameters on in vitro and in vivo efficacy of mRNA/delivery vehicles nanoparticles.
• Interface with other team members in the formulation group as well as in other functions with the scope to constantly improve delivery of the target molecule as well as formulation techniques.
• Collaborate with other members to design high-throughput screening tests to evaluate efficacy and safety of the formulations developed.
• Coordinate activities to translate new bench scale compositions to larger volumes for clinical testing.
• Maintain an accurate and detailed record of experiments.
• Cross-functional collaboration to ensure project success.
• Manage lab supplies (chemicals, glassware, etc.).
• Communicate results and actively participate in scientific discussions and group meetings.

PROFESSIONAL EXPERIENCE / QUALIFICATIONS

• BS, MS or Ph.D. degree in chemical or biomedical Engineering or related field.
• Relevant industrial experience in drug delivery or nanoparticle formulations is preferred. 
• A deep knowledge of current methods for non-viral delivery of nucleic acid (mRNA, RNAi, etc..) including lipid nanoparticles (LNP), liposomes, and/or polymeric nanoparticles and/or experience in tangential flow filtration is a plus.
• Hands-on experience in designing, optimizing and characterizing formulations
• Proficiency in formulation analytics (DLS, zeta potential, UV-Vis and fluorescence spectrophotometry, etc…).
• Experience with handling of RNA as well as familiarity with RNA-related analytics (e.g., RiboGreen assay, gel electrophoresis, etc.).
• Proficiency with MS Office.
• Outstanding interpersonal skills and established collaborative working habits.
• Excellent oral and written communication skills
• Organized, detail-oriented, self-starter who always seeks improvements.