Scientist - Analytical Development and Operations

POSITION SUMMARY

GreenLight Biosciences is seeking a highly motivated and collaborative scientist to join the Analytical Development team. This role is an exciting opportunity to support development of new LNP-mRNA vaccine candidates to help advance the company’s pipeline and RNA platform technology. The incumbent will use expertise in early and late stage/commercial development to develop, qualify, and support analytical assays. The successful candidate will also help expand analytical assay capabilities and build standardized procedures and new platforms. In this role you will work alongside a team of Scientists and Research Associates supporting research initiatives at our Lexington, MA location. Your team will be integrally involved in the development of novel methods to enable mRNA process development. The ideal candidate will have experience executing analytical methods to quantitate and characterize biomolecules, preferably nucleic acids. The ability to work collaboratively in a cross-functional team to deliver against aggressive deadlines is essential. Experience characterizing mRNA, lipids, and/or other small molecules via CE, and HPLC and various other techniques including qPCR, chemical derivatization and primer/probe design are preferred. Strong technical, organizational, and communication skills, and the ability and drive to maintain commitment to scientific excellence and high-quality work in a fast-paced, milestone-driven company are essential.

MAJOR RESPONSIBILITIES

• Significant experience and track record of successfully developing molecular biology assays using techniques like ddPCR, qPCR, etc. for the characterization and quantitation of products
• Evaluate various analytical techniques and instrumentation to deliver improved methods for the characterization of various RNA product concepts
• Knowledge of other biophysical or biochemical techniques like ELISA and H/UPLC is a plus.
• Develop sample preparation procedures to increase robustness of HPLC methods and allow higher throughput quantification, utilizing automated liquid handling where appropriate
• Apply DOE methodology to optimize assays for minimal CV and increased reproducibility
• Ensure accuracy of data and timely turnaround of results coming out of the Analytical Chemistry group
• Analyze, summarize, and present technical data to manager and other team members
• Work collaboratively with other R&D team members to accomplish project goals and milestones
• Strong attention to detail, problem solving abilities and a willingness to help wherever needed
• Stay up to date with scientific and technical development within the field of analytical chemistry

PROFESSIONAL EXPERIENCE / QUALIFICATIONS

• 2+ years’ experience, preferably in an analytical chemistry group at an industrial biotechnology company; relevant graduate research will be considered
• Strong background in chemistry, with knowledge of nucleic acid chemistry, biochemistry, and microbial metabolism a plus
• Method development experience, with a proven track record of successfully developing sample extraction methods and robust, quantitative and qualitative assays
• Experience with nucleotide and oligonucleotide / nucleic acid separations is preferred
• Familiarity with diverse analytical techniques for metabolite detection/quantification
• Hands on experience troubleshooting analytical equipment is a plus
• Experience with Capillary electrophoresis is required
• Must be highly motivated with high quality standards for one’s own work, strong communication skills, and an absolute commitment to team success

EDUCATION

• Ph.D. or M.S. in analytical chemistry, chemistry, biochemistry, chemical engineering, or related field