Integrated Safety Analysis (ISA) Engineer

General Matter, Inc. is an American nuclear energy company based in California that is focused on developing domestic nuclear energy solutions. The company aims to harness nuclear technology to increase national energy prosperity, reduce dependence on foreign energy sources, and support the expansion of American capabilities in the energy sector. Their work centers on making nuclear energy more accessible and practical by advancing technologies that can be developed and deployed within the United States. General Matter's mission is rooted in the belief that nuclear power represents a critical pathway toward a cleaner, more energy-independent future. By turning domestic nuclear potential into operational reality, the company positions itself at the intersection of national security, economic growth, and climate-conscious energy production. Their approach emphasizes building nuclear energy infrastructure that is homegrown rather than reliant on foreign supply chains or expertise. The company brings together leaders from nuclear engineering, technology, government, and finance, reflecting a multidisciplinary approach to solving the complex challenges of modern nuclear energy development. As a startup operating in the green and climate technology sector, General Matter represents a new wave of private investment in nuclear energy as a viable and scalable low-carbon power source for the United States.

 

About This Role

As an ISA Engineer at General Matter, you will build the safety basis for a new NRC-licensed enrichment facility under 10 CFR Part 70. You will not inherit a 20-year-old ISA Summary and run change packages. You will develop the hazard analyses, accident sequences, and IROFS from the ground up, and your conclusions will shape the design while it is still on the drawing board. You will work directly with process, controls, and operations engineers, and you will be a technical voice in our NRC interactions. This is a mission of national importance, and few engineers get to take a Part 70 safety basis from a blank page through license application and into operation.

If you seek high impact and are excited by fast-paced, intense, Skunkworks-style projects, we encourage you to apply to join our team.

Responsibilities

• Own and develop Integrated Safety Analyses per 10 CFR Part 70 Subpart H and NUREG-1520, including hazard identification, accident sequence development, consequence analysis, and likelihood evaluation.
• Lead process hazard analyses (HAZOP, What-If, FMEA) with design and operations teams, and drive the resulting actions to closure.
• Define, evaluate, and maintain IROFS and management measures, and work with designers to favor inherently safer process choices over layered administrative controls.
• Develop and maintain the ISA Summary, safety basis change packages, and supporting technical analyses for the license application.
• Assess risks across nuclear criticality safety, chemical hazards (including UF6 and process chemicals), fire protection, and natural phenomena and external hazards.
• Support NRC interactions, including audits, inspections, and responses to requests for additional information.
• Participate in design verification, configuration management, and change control for modifications that affect the safety basis.
• Support startup, commissioning, and operational readiness as the facility moves from design to operation.

Basic Qualifications

• Bachelor’s degree in Chemical, Mechanical, or Nuclear Engineering, or a related field. An MS, MBA, or PhD may substitute for 2–3 years of experience, depending on degree level.
• 4+ years of experience in nuclear safety, process safety, or similar high-hazard environments.
• Working knowledge of safety analysis methods such as PHA, Criticality Safety Analysis, Fire Hazard Analysis, and External Hazard Analysis.
• Evidence of exceptional ability (prior projects, portfolio of work, completed products, etc.).
• Strong analytical skills and attention to detail, and the ability to explain technical safety conclusions clearly, in writing and in person, to engineers, operators, and regulators.
• Ability to work collaboratively across engineering, operations, and licensing teams.

Preferred Skills and Experience

• 8+ years of experience in nuclear safety, process safety, or similar high-hazard environments.
• Direct experience with ISA, ISA Summaries, IROFS, SARs, and risk determination at a Part 70 facility, or with DSA/SAR work under DOE 10 CFR 830.
• Experience with an NRC Part 70 license application or RAI responses.
• Petrochemical or PSM experience (HAZOP, LOPA, SIL). This is a strong substitute for nuclear experience, and we know the methods transfer.
• Knowledge of UF6 hazards, vacuum systems, cryogenics, compressible flow, or nuclear chemical processes.
• Experience in a fast-paced, resource-constrained environment where a resourceful, entrepreneurial approach was required to meet tight timelines.
• Familiarity with NRC safety standards and the associated regulatory framework.

Additional Requirements

• Ability to work extended hours and weekends as necessary.

Equal Opportunity Employer

General Matter is an Equal Opportunity Employer; employment with General Matter is governed on the basis of merit, competence and qualifications and will not be influenced in any manner by race, color, religion, gender, national origin/ethnicity, veteran status, disability status, age, sexual orientation, gender identity, marital status, mental or physical disability or any other legally protected status.

Compensation and Benefits

The base salary range for this role is $100,000–$200,000 annually.
Compensation bands are determined by role, level, location, and alignment with market data. Individual level and base pay is determined on a case-by-case basis and may vary based on job-related skills, education, experience, technical capabilities and internal equity. Please note that the stated salary range is an estimate and may be adjusted based on market conditions, business needs, or other factors. In addition to base salary, for full-time hires, you may also be eligible for long-term incentives, in the form of stock options, and access to medical, vision & dental coverage as well as access to a 401(k) retirement plan.